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It should be noted that changes in other lipid species that are relevant to liver injury and inflammation, such as acyl-CoAs, diacylglycerides, ceramides and sphingolipids 42 , were not investigated in the present study

After meticulous screening for eligibility, 24 trials comprising 22,185 patients that met the inclusion criteria were included in the meta-analysis

The maximum dose is 15 mg weekly, typically achieved after 21 weeks of treatment if the Mounjaro dosage schedule is followed correctly

Implementation: Administer MOTS-c 30-45 minutes before the largest meal of the day, typically lunch or dinner depending on individual eating patterns